Mitochondrial Apoptosis and the Peripheral Benzodiazepine Receptor
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چکیده
منابع مشابه
Mitochondrial Apoptosis and the Peripheral Benzodiazepine Receptor
Viruses mercilessly exploit their host cells to guarantee their own proliferation and propagation. To achieve this goal, many viruses suppress the apoptotic program, thereby avoiding premature death of the host cell. Indeed, apopto-sis of infected cells may be considered as a pristine defense against infectious pathogens, as illustrated by a simple Gedankenexperiment : if all host cells died im...
متن کاملMitochondrial Apoptosis and the Peripheral Benzodiazepine Receptor: A Novel Target for Viral and Pharmacological Manipulation
Viruses mercilessly exploit their host cells to guarantee their own proliferation and propagation. To achieve this goal, many viruses suppress the apoptotic program, thereby avoiding premature death of the host cell. Indeed, apopto-sis of infected cells may be considered as a pristine defense against infectious pathogens, as illustrated by a simple Gedankenexperiment : if all host cells died im...
متن کاملPeripheral benzodiazepine receptors and mitochondrial function.
For over 20 years, numerous investigations have focused on elucidating the function of the peripheral benzodiazepine receptor (PBR). This relatively small protein (18kDa) arouses great interest because of its association with numerous biological functions, including the regulation of cellular proliferation, immunomodulation, porphyrin transport and heme biosynthesis, anion transport, regulation...
متن کاملEnigma of the peripheral benzodiazepine receptor.
Rappaport Family Institute for Research in the Medical Sciences, Haifa, Israel (M.G.); Department of Pharmacology (M.G., I.B., R.S., L.V.) and Laboratory for Research in Anesthesia, Pain and Neuroscience (Y.K.), The Bruce Rappaport Faculty of Medicine, TechnionIsrael Institute of Technology, Haifa, Israel; Department of Anesthesiology, Ha’Emek Medical Center, Afula, Israel (Y.K.); Endocrinology...
متن کاملThe peripheral-type benzodiazepine receptor. Localization to the mitochondrial outer membrane.
We have investigated the subcellular localization of the peripheral-type benzodiazepine receptor in rat adrenal gland using the high affinity ligand 3H-labeled 1-(2-chlorophenyl)-N-methyl-(1-methylpropyl)-3-isoquinoline carboxamide ([3H]PK11195). The autoradiographic pattern of [3H]PK11195 binding sites in tissue sections of adrenal gland is similar to the histochemical distribution of the mito...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2002
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.20021758